December 05, 2008
The ACCOMPLISH* study demonstrated that a combination of benazepril and amlodipine was superior to the combination of benazepril and hydrochlorotizide in reducing cardiovascular events in patients with hypertension who were at risk for such events.
“This study could definitely change current treatment guidelines for hypertension“ said associate professor Björn Dahlöf, Sahlgrenska University Hospital, Göteborg, member of the executive committee of the ACCOMPLISH trial.
Drawing from the previous experience of large clinical trials A+ Science generated high-quality data collected from a total of 154 clinical investigators participating in Denmark, Finland, Norway and Sweden.
"Through careful selection, monitoring and follow-up of the randomized patients we maximized quality and kept the amount of lost data to a minimum” says Ola Jeppsson, Senior CRM and Large Clinical Trials Manager at A+ Science. “In fact no patients were lost to follow-up among the 3,354 patients randomized in the Nordic countries.”
A+ Science would like to take this opportunity to thank all participating investigators and patients for their valuable contribution.
*The Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial
For further information read the abstract at:
The New England Journal of Medicine
N ENGL J MED 2008; 359:2417-2428 December 4, 2008
The Accomplish study has been published in several other prestigious medical papers:
Rationale and Design of the Avoiding Cardiovascular events through COMbination therapy in Patients LIving with Systolic Hypertension (ACCOMPLISH) Trial
American Journal of Hypertension, Ltd, 2004; 17:793-801
Exceptional early blood Pressure control rates: The ACCOMPLISH trial
Blood Pressure. 2007; 16: 80-86
Baseline characteristics in the Avoiding Cardiovascular events through Combination
Therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial: A hypertensive population at high cardiovascular Risk
Blood Pressure. 2007; 16: 13-19
Predictors of blood pressure response to intensified and fixed combination treatment of hypertension: The Accomplish Study
Blood Pressure. 2008; 17: 7-17
Return to news list